Meanwhile, much longer dietary interventions, for example 10 months of a high fat (35%) formula to the triple transgenic (3xTg-AD) mice increased Aβ 40 and 42 concentrations and tau, suggesting that high-fat consumption promotes Alzheimer's disease-like neuropathology (Julien et al., 2010). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.