In our meta-analysis, there were six publications including a total of 1,007 cases and 1,487 controls examined the relationship between Helicobacter pylori infection and GSTM1 polymorphism for the risk of gastric cancer, and some risk excess was observed among Helicobacter pylori infection positive individuals compared with negative individuals by combining the data available from these six studies. This evidence concerns the gene GSTM1 and gastric cancer.