Regarding circulating factors, the mean concentrations of insulin and C-reactive protein were above normal values (Table 2) [21, 22]; yet 20% of children presented calcium concentration <10 mg/dL, and 3.8% presented deficiency (<12 ng/mL) and 32.86% insufficiency (between 12 and 20 ng/mL) of 25-OHD3. The gene discussed is CRP; the disease is hyperinsulinemic hypoglycemia, familial, 4.