However, there was a suggestion of a significant interaction by diabetes status in the effect of PON1 L55 on ox-LDL levels (interaction P = 0.013), with suggestion of a positive effect on ox-LDL levels in participants with diabetes and a negative or no effect in participants without diabetes (β = −395.49, P = 0.075) for the main effect of the variant in the multivariable model containing the interaction term gene*diabetes. The gene discussed is PON1; the disease is diabetes mellitus.