Memantine, which passed clinical trials and is in use to treatadvanced Alzheimer`s disease, might show similar effects as the specificKv1.3 and KCa3.1 blockers Shk andTRAM-34 in treating allograft vasculopathy or kidney allograft rejection[80,81]. The gene discussed is KCNN4; the disease is early-onset autosomal dominant Alzheimer disease.