Compared with reactive hyperplasia, long and short isoform of c-FLIP gene (c-FLIPL and c-FLIPS) were overexpressed in patients with PTCLs and T-cell acute lymphoblastic leukemia (T-ALL) (P all <0.001, Figure 1A), in agreement with significant downregulation of extrinsic apoptosis-inducing signaling ligand TRAIL and its receptor DR5 (P all <0.001, Figure 1B). This evidence concerns the gene TNFRSF10B and T-cell acute lymphoblastic leukemia.