CD40LG and Sepsis: Plasma level of miR-150 was significantly downregulated in sepsis, corroborating our previous results with a different patient cohort.18 Given the facts that miR-150 in B lymphocytes has been shown to be downregulated following activation by IgM-specific antibodies or LPS19 and that miR-146 is involved in innate immunity by regulating the inflammatory response after pathogen recognition by TLRs on monocytes and macrophages,20 our results further support their roles as plasma sepsis biomarkers.