In this study, we investigated the effect of FTS on human AML cells, which were shown to serve as a model for LAM.7 Using a gene array method, we demonstrate that FTS, by targeting Rheb, can inhibit the function of IRF7 in AML cells, thereby mimicking the effects of rapamycin and re-expression of TSC2. Here, RHEB is linked to acute myeloid leukemia.