TSC2/mTORC1 has been shown to have an important role in the generation of IFN-induced responses.28 Moreover, gene array analysis conducted previously on TSC complex cortical tubers, also revealed a connection between mutations in TSC genes and inflammation.29 It showed elevation of inflammatory gene expression in the tumor tissue, including CCL2 and GBP1, which were also seen elevated in our study in AML cells. Here, TSC1 is linked to acute myeloid leukemia.