Starvation-induced pseudodiabetes is benevolent because they are associated with inhibited mTOR.67 In contrast, in the modern time, IR (as we know it) is associated with obesity and leads to diabetes type II.40, 13 This harmful IR is associated with over-activation of mTOR and aging (Figure 2). Here, MTOR is linked to obesity due to melanocortin 4 receptor deficiency.