CR extends life span in numerous species from worm to mammals.11, 28, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81 CR prevents age-related diseases including cancer and sarcopenia.82, 83, 84 Whereas moderate CR increases insulin sensitivity, severe CR causes signs of IR.85 Among individuals who had been practicing severe CR, 40% of CR individuals showed ‘diabetic-like' glucose intolerance.85 In theory, starvation would be beneficial for health, but cannot last long enough for obvious reason – death from starvation. This evidence concerns the gene INS and Glucose intolerance.