Recent publications, including our reports, demonstrated an important role of XRCC1 in repair of cisplatin-induced DNA damage and apoptosis in cancer cells.9, 11, 27, 43 The JWA, an upstream regulator of XRCC1, was demonstrated to be involved in cellular responses to environmental stress including oxidative stress by upregulating the expression of XRCC118, 19 and demonstrated the prognostic and predictive role of XRCC1 and JWA protein expressions in GC tissue.26 The gene discussed is ARL6IP5; the disease is cancer.