Previous studies indicated a tumor suppressor role of JWA as it was downregulated during tumor development, for example, knockdown of JWA expression promoted tumor metastasis by integrin aVb3 signaling in melanoma.23 Inhibiting expression of JWA promoted angiogenesis in melanoma and GC.44, 45 Knockdown expression of JWA lead to increased survival of HeLa and MCF-7 cells by treatment with As2O3. This evidence concerns the gene ARL6IP5 and melanoma.