It was previously reported that JWA is required for apoptosis induced by chemotherapeutics such as As2O3 and VP16 in cancer cells.25, 28 Here, two GC cell lines BGC823 and SGC7901 were used to investigate the role of JWA in apoptosis triggered by cisplatin-induced DSBs. The gene discussed is ARL6IP5; the disease is gastric cancer.