The expression level of Linc00974 was knocked down by two independent shRNA plasmids and was confirmed to be stably downregulated in the two cell lines mentioned above; shRNA-1 was applied to detect the biological significance of Linc00974 on tumor growth and metastasis with better efficiency while KRT19 was also knocked down by shRNA (Supplementary Figures S2A–C). Here, KRT19 is linked to neoplasm.