This is based on the genetic associations between APOE variants and many age-related diseases, such as coronary heart disease (Ward et al., 2009), atherosclerosis (Davignon et al., 1988), age-related macular degeneration (AMD) (Klaver et al., 1998), and Alzheimer's disease (Saunders et al., 1996). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.