The tetracycline-inducible overexpression of IRP1 or IRP1C437S mutant results in misregulation of iron metabolism, highly active in IRE-binding and increased TfR1 levels in human H1299 lung cancer cells (Wang and Pantopoulos, 2002), but not altering the growth properties of the H1299 cells invitro (Wang and Pantopoulos, 2002). Here, TFRC is linked to lung carcinoma.