RYR1 and Malignant hyperthermia: Polymorphic variation at codon 2347 was not present in >13,000 RYR1 alleles reported on the exome variant server (http://evs.gs.washington.edu/EVS), but the c.7043delGAG deletion was previously described, in the heterozygous state, in affected members (total 5 cases) of two unrelated families that presented with malignant hyperthermia [16].