In particular, a 156-fold increase was observed for TMEM241. Overall, there was a remarkable overlap between the most over- (TMEM241, CMBL, ZNF445, SPRR4) and under-expressed (PF4V1, FLJ22184, FSIP2, PPP1R3B, HIST3H3, PIF1, SPSB4, ILDR1, MAP3K10, DRD4, LBX1, TSPAN10) genes in DS and in non-DS AMKL samples (Additional files 4 and 5). This evidence concerns the gene ZNF445 and Dravet syndrome.