The second segment was specific of non-DS AMKL samples and included the two olfactive receptor genes OR10A5 and OR10A4. The only significantly under-expressed segment included the region on chromosome 4 (4q12-q21) highly enriched in MK-specific loci (PF4, PPBP, CXCL5 and CXCL3) as in the case of DS AMKL samples, and was extended to PF4V1 locus. This evidence concerns the gene PF4V1 and acute megakaryoblastic leukemia.