ICOS and rheumatoid arthritis: We observed that both RA patients with active disease and RA patients with inactive disease demonstrate an increased frequency of cTfh (CD3 + CD4 + CXCR5 + ICOS+) together with an overrepresentation of cTfh subsets bearing a phenotype associated with B cell helping capacity (CD3 + CD4 + CXCR5+ CCR6 + CXCR3- and CD3 + CD4 + CXCR5 + CCR6-CXCR3-).