NFKB1 and inflammatory response: These findings were replicated in colonic biopsies in patients with active UC.152 Conversely, NFκB has also been shown to play an anti-inflammatory role in IBD as demonstrated by the differential expression of miR-146b in IL-10 deficient mice models.150 Administering miR-146b vectors intraperitoneally in DSS colitis mice ameliorated intestinal inflammation via activation of the NFκB mediated pathway.150