The parameters which were found by univariate analysis to have the greatest effect on overall survival were ECOG PS≥2, WBC≥10.000, high LDH level, high ALP level, hypercalcemia, albumin <3 gr/dL, number of metastases>2, presence of pleural effusion, brain, liver, surrenal and bone metastases and number of chemotherapy cycles ≥4. The gene discussed is ALB; the disease is Pleural effusion.