ALB and Pleural effusion: A multivariate analysis showed that ECOG PS≥2 (HR: 1.33, 1.06–1.66, p = 0.014), high LDH level (HR: 1.31, 1.00–1.70, p = 0.047), serum albumin <3 g/dL (HR: 1.28, 0.98–1.67, p = 0,037), serum calcium>10.5 g/dL (HR: 1.46, 1.09–1.96, p = 0.011), metastases number>2 (HR: 2.11, 1.42–3.14, p<0.0001), presence of metastases (HR: 1.73, 1.11–2.71, p = 0.016), presence of pleural effusion (HR: 1.98, 1.33–2.94, p = 0.001), and a number of chemotherapy cycles ≥4 (HR: 0.53, 0.38–0.73, p<0.0001) were found to be related to OS as independent prognostic factors.