Our recent study revealed that maternal hypoxia exposure represses GR expression in the developing brain, resulting in heightened susceptibility to neonatal HI brain injury, while pretreatment with dexamethasone, a selective GR agonist, confers neuroprotective effects and reverses maternal hypoxia induced pathological process, which confirmed the pivotal role of GR actions in the brain development and pathology [6]. Here, NR3C1 is linked to injury.