Because these differences in survival could not be explained by significant differences in mean values of TcpA-specific or CTB-specific serum IgG or fecal IgA antibodies among groups of pups from dams immunized with vaccine formulations that contained any form of TcpA or CTB, respectively (see Figs. 5 and 6), our results constitute strong preliminary evidence that anti-TcpA and anti-CTB antibodies act synergistically rather than additively to prevent death in the infant mouse model of cholera. The gene discussed is CD79A; the disease is vibrio infectious disease.