Both ECM and HCM are characterized by severe vasculopathy, i.e. endothelial activation and dysfunction with increased expression of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin, upregulation of inflammatory cytokines, reduced blood flow, vascular leakage, acute edema of both vasogenic and cytotoxic origin, and microhemorrhages leading to neurological impairment [12]–[17]. This evidence concerns the gene ICAM1 and vascular disorder.