Sensitivity analyses were performed by excluding the following studies successively: EARSS study [20], which was abstract from conference proceedings; ALBIOS study [21], in which the primary aim of albumin-containing fluids administration was not for initial resuscitation; small studies (<100 patients) [22]–[25], [26]–[31]; large studies (>100 patients) [13], [20], [21], [31], [36], [37]; and studies [26], [30], [31] on malaria which has a pathophysiology with many features in common with sepsis [39]. This evidence concerns the gene ALB and malaria.