In ADPKD, renal cells have multiple anomalously activated signaling proteins relevant to these processes, including ribosomal protein S6 (S6), ribosomal S6 kinase (RSK/S6K), AKT, mammalian target of rapamycin (mTOR), SRC, ERK1/2, and RAF, among others [1], [2]. The gene discussed is MTOR; the disease is autosomal dominant polycystic kidney disease.