Reversa mice were maintained on Western diet for 16 weeks, which allowed for the development of hypercholesterolemia (903±71 mg/dL total cholesterol [mean ± standard error, SE]) and substantial, macrophage-rich plaques at the aortic root, as determined by immunostaining with the macrophage marker Cluster of Differentiation 68 (CD68). The gene discussed is CD68; the disease is familial hypercholesterolemia.