LRP6 and coronary artery disorder: Additionally, we measured mRNA levels of two known Wnt target genes, Lrp6 (for which loss-of-function has been associated with premature CAD [66]) and Gja1[67], both of which were indicated by microarray profiling to be upregulated in regressing vs. progressing plaque CD68+ cells in the aortic transplant model [36].