CD68 and coronary artery disorder: While the 213 genes we identified as differentially expressed in plaque CD68+ cells in the Reversa mouse in response to lipid lowering are likely only a subset of the transcriptional changes in plaque macrophages over various time points, the enrichment of atherosclerosis/CAD risk alleles within human monocyte expression QTLs for orthologs of these genes (Figure 2C) provides intriguing support for their collective function in macrophages in the context of atherosclerosis.