While the 213 genes we identified as differentially expressed in plaque CD68+ cells in the Reversa mouse in response to lipid lowering are likely only a subset of the transcriptional changes in plaque macrophages over various time points, the enrichment of atherosclerosis/CAD risk alleles within human monocyte expression QTLs for orthologs of these genes (Figure 2C) provides intriguing support for their collective function in macrophages in the context of atherosclerosis. This evidence concerns the gene CD68 and atherosclerosis.