Protein expression analysis in hippocampal CA1 pyramidal neurons of aged Ts65Dn mice revealed a decrease in the levels of several neurotrophins and their cognate receptors, subunits of glutamatergic AMPA and NMDA receptors, and other changes [32] similar to those observed in AD [47], [48], [49], [50]. Here, BDNF is linked to Alzheimer disease.