For example, Ts65Dn mice tested in the ‘marble burying’ assay, a test for compulsive behavior and anxiety, showed no effect with a low dose of JZL184 (4–8 mg/kg) but a decrease in burying activity with a higher dose (40 mg/kg), while genetic deletion or pharmacological inhibition of FAAH, which selectively increased levels of AEA, reduced anxiety-like behaviors in the elevated plus maze [67], [68], [69], zero maze [70], and light/dark box [41]. Here, FAAH is linked to Anxiety.