Also, it was recently observed that overexpression of Dyrk1a, one of the genes triplicated in Ts65Dn mice and DS, resulted in the ablation of endocannabinoid-mediated long-term depression in the prefrontal cortex, while JZL184 treatment restored this type of synaptic plasticity [87]. This evidence concerns the gene DYRK1A and Dravet syndrome.