NFKBIA and hepatocellular carcinoma: As shown in Figure 5G and H, transfection of an IκBα dominant-negative mutant (IκBα-mut) or treatment with a NF-κB inhibitor abrogated the ability of AGK-overexpressing cells to promote tubule formation by HUVECs and reduced the ability of HCC cells to resist apoptosis induced by cisplatin.