The ability of catecholamines to induce in melanoma cells the expression of the pro-inflammatory and pro-angiogenic interleukin-6 (IL-6), interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) prompted us to study the role of β-AR functions within tumor microenvironment [20, 21]. This evidence concerns the gene ADRB2 and melanoma.