Infection with a 5-fold higher dose of parasites was required to elicit the extent of increase in inflammatory infiltrate in skeletal muscle (score: 2–4, Fig. S1.d&e) and heart tissue (score: 1–2, Fig. S1.i&j) of WT mice as was noted in skeletal muscle and heart tissue of p47phox−/− mice infected with 2,000 parasites. The gene discussed is NCF1; the disease is infection.