AGT and Hypertension: Nevertheless, the results are straightforward and similar in that hypertension developed gradually in both groups of control animals during peripheral AngII infusion and this was markedly attenuated after several days in animals over-expressing CuZnSOD; thus, equally implicating O2·−-dependent signaling in the SFO and the MnPO as a mechanism driving the chronic hypertensive effects of AngII.