AGT and hypertensive disorder: In both studies, animals centrally injected with AdCuZnSOD had a marked attenuation of AngII hypertension, although the previous study utilized a mouse model that received AngII subcutaneously via osmotic minipump at a dose of 600 ng/kg/min over 16 days compared to the present study which utilized continuous IV infusion for 10 days at a dose of 10 ng/kg/min.