PRB2 and atherosclerosis: In systemic lupus erythematosus (SLE), where the risk of CVD and accelerated atherosclerosis is increased, anti-phospholipid antibodies against cardiolipin and phosphatidylserine (anti-CL and anti-PS) have been much discussed and are generally recognized as risk factors for CVD in SLE, typically when present in very high levels as compared to controls.