The results showed that, after treatment with oncolytic adenovirus, the expressions of Hexon and Hsp70 in the AdSurp-Hsp70+CIK and AdSurp-Hsp70 groups, as well as the expression of Hexon in the AdSurp-EGFP group, were confined within the cancer cells (Fig.4A-B), indicating that oncolytic adenoviruses can target the Survivin-positive HCC cells and replicate in tumor cells with specific expression of the therapeutic gene Hsp70. This evidence concerns the gene BIRC5 and neoplasm.