One method used an oncolytic adenovirus regulated by a tumor-specific Survivin gene promoter to mediate the targeting expression of Hsp70 or P53 gene [1,2], the other method involved using an oncolytic adenovirus regulated by the carcinoembryonic antigen (CEA) gene promoter to mediate the targeting expression of Hsp70 gene [3]. The gene discussed is CEACAM5; the disease is neoplasm.