NSCLC subgroups defined by the occurrence of distinct oncogenic driver mutations are mostly characterized by certain phenotypic characteristics like female gender, adenocarcinoma histology and never-smoking status in EGFR-mutated or ALK-translocated NSCLC or squamous cell histology and heavy-smoking history in FGFR1-amplified NSCLC [7]. The gene discussed is FGFR1; the disease is non-small cell lung carcinoma.