In this study, we also found that FGF8 can induce a fibroblastic change in RKO cell morphology, with altered EMT-specific gene expression, including repression of E-cadherin and activation of Snail and Vimentin, indicating that FGF8 contribute to CRC metastasis by inducing EMT (Figure 3, Figure S2). This evidence concerns the gene CDH1 and colorectal carcinoma.