In this study, we found that FGF8 can induce activation of YAP1 signaling, and silencing of YAP1 reversed FGF8-induced proliferation, migration and invasion in CRC cells, suggesting YAP1 is important in the acquisition of an aggressive phenotype in FGF8-treated CRC cells (Figure 6-7 and S3-5). This evidence concerns the gene FGF8 and colorectal carcinoma.