As an example, in prostate cancer rearrangements occurred between untranslated exon 1 of SLC45A3 (a prostate-specific androgen responsive gene) and exon 8 of BRAF (GenBank GU149303) or between exon 13 of ESRP1 (an epithelial splicing regulatory protein) and exon 6 of RAF1 (GenBank GU149302). Here, ESRP1 is linked to Familial prostate cancer.