Studies with azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse models of colitis-associated colon cancer (CAC) and animal models carrying a conditional disruption of IKKβ have been used to show that IKKβ-driven NF-κB activation within intestinal epithelial cells (IECs) is essential for CRC development [8–10]. This evidence concerns the gene IKBKB and colorectal carcinoma.