Immunohistochemistry for TTBK1, TTBK2 and phospho-TDP-43 was performed on frontal cortex sections from 6 FTLD-TDP cases, 6 ALS cases and 6 normal control cases to determine if there was overlap in the expression of these kinases and their purported target. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.