Interestingly, phosphorylated TDP-43 is also present in a subset of patients with primary tauopathies such as AD, PSP, and CTE [8], [47], [48], and either tau or TDP-43 are the diagnostic pathologic changes in the vast majority of frontotemporal lobar degeneration cases [49]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.