Taken together Figs. 4, 5 and 6 repeatedly demonstrate an overlapping expression pattern for TTBK1/2 and pS409/410 TDP-43 inclusions in ALS and FTLD-TDP consistent with TTBK1/2 participation in the genesis of TDP-43 lesions. Here, TTBK1 is linked to amyotrophic lateral sclerosis.