In a murine model of sepsis, the high affinity orthosteric agonist, ATL313, decreases circulating plasma levels of pro-inflammatory cytokines and chemokines such as TNF-α, MIP-1α, MCP-1 [26] and increases the plasma level of the anti-inflammatory cytokine IL-10 [26] within 4 h of LPS injection. The gene discussed is TNF; the disease is Sepsis.