After adjustment for known risk factors of CRC (age, gender, BMI, WHR, family history of CRC, alcohol intake) and for statin use, recent weight loss and serum pre-albumin, we observed a significant association between serum NGAL and the risk of CRC (3rd versus 1st tertile, OR: 2.76; 95% CI:1.59-4.78) (Table 3). This evidence concerns the gene LCN2 and colorectal carcinoma.