Misregulation (both overproduction and downregulation) of Ndc80/Hec1, TACC, TOG and kinesin-8s protein levels are associated with the grade of tumour in different cancers (Diaz-Rodríguez et al., 2008; Wu et al., 2008; Rath and Kozielski, 2012; Ha et al., 2013). This evidence concerns the gene CKAP5 and neoplasm.