Moreover, a 7.4-kb cis-regulatory deletion disrupting conserved noncoding sequences and their interaction with the promoter of another FOX gene, FOXL2, mapping more than 280 kb apart, has been described as pathogenic for blepharophimosis, ptosis, and epicanthus inversus (BPES; OMIM 110100) [34]. This evidence concerns the gene FOXL2 and ptosis.