Previous reports have shown that excess phosphorylation at Ser337 by GSK3 or at Ser636 by JNK1 and phospho‐mTOR can cause insulin resistance by preventing insulin receptor‐mediated tyrosine phosphorylation of IRS‐1 (Ozes et al. 2001; Liberman and Eldar‐Finkelman 2005). This evidence concerns the gene IRS1 and Insulin resistance.