Panobinostat strongly downregulated High Mobility Group AT-2 hook (HMGA2), a nuclear non-histone transcriptional co-factor with known oncogenic properties, in HepG2 and Hep3B cells and the effect was found to be mediated by transcriptional upregulation and promotion of the maturation of the tumor suppressor miRNA hsa-let-7b, which could inhibit HMGA2 expression via RNA interference pathways [13]. Here, HMGA2 is linked to neoplasm.