FOXO1 and hepatocellular carcinoma: Importantly, western blotting analysis showed that FOXO1 expression was downregulated in the eight pairs of HCC tissue, compared with the adjacent noncancerous hepatic tissues, and statistical analysis revealed that miR-1269 levels inversely correlated with the expression of FOXO1 in the clinical HCC samples (Figure 4B), suggesting that miR-1269 might play role in regulation of FOXO1 in HCC.