But this study also found that both Bcl-2 protein expression and mRNA expression were significantly higher in myocardial cells in rats with depression and myocardial ischemia than in the depression group, suggesting the apoptosis-inhibiting Bcl-2 gene was also involved in the process of ischemia/reperfusion inducing myocardial cell apoptosis in rats. This evidence concerns the gene BCL2 and major depressive disorder.