NR0B2 and alkaline phosphatase measurement: In an initial experiment in wild-type mice, we observed that expression of ileal Fxr target genes Fgf15, Shp and Ibabp (Figure 1C) was disturbed at 24 hrs after induction of AP, while expression levels recovered at the time point that histopathological damage of the pancreas had largely resolved (i.e. 72 hrs after AP induction).