In the first report of BLK influence in SSc genetic predisposition, the combined analysis of Caucasian US and European cohorts revealed the association of the minor allele of two genetic variants (rs13277113 and rs2736340) with increased susceptibility to SSc, and specifically with the lcSSc and Anti-centromere antibody (ACA) positive subsets [3]. Here, BLK is linked to systemic sclerosis.