For example, the proteomic profile obtained by Martinez et al.[29] from frontal cortex homogenates of patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder characterized by neuronal loss and gliosis, resulted in the discovery of PGK-1 and aldolase A as targets of oxidation in oxidative stress. Here, PGK1 is linked to Classical progressive supranuclear palsy.