The down-regulation of GAPDH (spot e in figure 3) in He and Ho (around 1.8-fold change compared to control) was in agreement with data from the literature and the oscillation pattern of changes of α-enolase (spot c in figure 3), although rather confusing (down-up-down), was coincident with results recently obtained by Takano et al.. on AD model mice [52]. This evidence concerns the gene GAPDH and Alzheimer disease.