In this paper, we evaluated the role of Casp6 in colon carcinogenesis because (1) Casp6 is observed to be highly expressed in human fetal and adult colons [20], (2) Casp6 is increased in human colon cancers compared to adjacent normal tissues [20], (3) rare mutations of Casp6 were observed in human colorectal cancers [24], and (4) Casp6 in implicated in the apoptosis of colon cancer cell lines [40], [41], [42], [43], [44]. This evidence concerns the gene CASP6 and colonic neoplasm.