Table 3 shows the distribution of the BDNF genotypes according to stroke severity. Logistic regression analyses were then used to determine the effect of genetic variables on stroke severity after adjusting for age and sex (model A), as well as traditional risk factors and stroke subtype (model B). The minor alleles of rs6265 and rs2049046 had a trend toward more severe stroke, whereas rs11030107 and rs11030119 had a trend towards milder stroke. However, no significant association was found between severity of stroke and any of the BDNF variants. This evidence concerns the gene BDNF and Stroke.