Our result showed that serum level of MMP9 decreased in patients with salivary gland tumors which suggest that MMP9 may not have a potential role in development and pathogenesis of salivary gland tumor but this preliminary result may form the basis for future investigations to investigate the role of active MMP-9 in pathogenesis and progression of salivary gland tumor. Here, MMP9 is linked to tumor of salivary gland.