Moreover, ameloblastoma and OKC have same biological behavior and both lesion relapse after treatment.[6-8] Therefore, the aim of this study was to determine the MVD by immuno histochemically adopting CD34 and CD105 in odontogenic keratocysts and ameloblastoma and evaluating any possible relationship between these markers and the biological behaviors of these lesions. This evidence concerns the gene CD34 and Keratocystic odontogenic tumor.